Low Dose Naltrexone (LDN)

Low-dose naltrexone is an opioid receptor antagonist which blocks opioid and endorphin receptors. In a standard dose, it is used to treat opioid overdose or to help with addiction management. At a low dose (0.001mg - 16mg) LDN has been shown to be anti-inflammatory and pain-reducing. 

Currently, providers are using LDN off-label for a variety of medical conditions such as:

  • Inflammatory bowel diseases (Crohn's and Collitus)
  • Chronic fatigue
  • Fibromyalgia
  • Hashimoto’s thyroiditis and other auto-immune diseases
  • Arthritis
  • Inflammatory conditions 
  • Chronic pain
  • Lupus
  • Restless leg syndrome
  • Autism 

Naltrexone’s effects on the body simplified are:

  • LDN increases naturally occurring endorphins, which help with pain and inflammation reduction
  • Increases the release of opioid growth factor
  • Reduces immune signaling through toll-like receptor 4, which is an immune cell that patrols the body for immune attack. These immune cells can keep the immune system in a hyper-sensitive state
  • Quiets the Glial cells in the brain which can cause inflammation of the nerves if too overactive
  • LDN increases dopamine levels

Side effects:

  • Vivid dreams
  • Headaches
  • Body aches
  • Mild agitation
  • Nausea or upset stomach
  • Decreases the effect of opioid medications used for pain management.
  • Rash
  • Dizziness

Side effects usually occur at the beginning of treatment or with dose increases. These can be reduced by cutting the dose in ½ for 2-3 days and resuming. 

LDN works with your own body so results and response time to the medication can vary. Experts recommend that at least 8 months of treatment is required to see maximal benefit. 

If you are looking for more information on LDN please follow the links below:



Please contact our providers today to speak to them to see if LDN may be right for you.